The human organism functions like a network of structured and interconnected systems, that influence and are influenced by the psychic dimension. Psychoneuroendocrinoimmunology (PNEI) is the study of the interaction between psychological processes and the nervous and immune systems of the human body. In this book PNEI paradigm presents itself in its full extension, according both to epistemology and physiology. Focused on the practical, preventive, and therapeutic implications of PNEI the Authors describe nervous, neuroendocrine, immune, psychic systems and their reciprocal influences, and show the modulation tools of the human network for preventive and therapeutic uses, such as nutrition, physical activity, psychotherapy, meditation and other behavioral and natural medicine techniques.